Paul Hendriksen in action at Bristol Golf Club Matthew Lewis
The 29-year-old shot a six-under-par 64 to finish five shots clear of second-placed Lee Mackie to lead home the six qualifiers for next month's final.
Hendriksen, who finished fifth in the Powerade PGA Assistants' Championship earlier this month, maintained his good form with a sparkling round that saw him hit the ground running with birdies at the first, fourth and fifth before an eagle at the seventh.
He returned a shot at the eighth but played the back nine in two-under with birdies at 15 and 17. Bristolian Trevor Jones (unattached) secured third spot with a one over par 71.
The final will be held at Batchworth Park on September 29, with the winner chasing a share of the £16,000 prize fund and a place in the English Open at St Mellion International Resort.
Results: 1 Paul Hendriksen (Fingle Glen) 64 (-6), 2 Lee Mackie (unattached) 69 (-1), 3 Trevor Jones (unattached) 71 (+1), 4= Russell Barry (Cleeve Hill), Andrew Ryan (Manor House), Alistair Welsher (Taunton & Pickeridge) 74 (+4)